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Gemma Figtree

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Gemma Alexandra Figtree AM is an Interventional Cardiologist at Royal North Shore Hospital, Professor in Medicine at the University of Sydney, chair of the Federal Government's 10-year Mission for Cardiovascular Health,[1][2] and co-leader of the Cardiovascular Theme for Sydney Health Partners.[3]

Career

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Figtree has dedicated her career to unravelling key mechanisms of heart attack susceptibility, combining clinical work as an interventional cardiologist with laboratory research, large cohort studies, and clinical trials.[3]

As a Rhodes Scholar at Oxford University, Figtree's cardiovascular research led to fundamental discoveries about estrogen and NO/redox regulation. Her research focuses on improving prediction, prevention and treatment of cardiovascular disease and heart attacks, inspired by her clinical work as an interventional cardiologist.[3]

Research

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Discoveries in her laboratory have been published in leading peer-reviewed journals, with over 190 publications cited ~9250 times.[3] Driven by patient care as an interventional cardiologist, Figtree's research reflects bench-to-bedside knowledge translation of molecular discoveries to the clinic, and her work with health digital twin technology[4] contributes to advances in precision medicine.

As a cardiologist spokesperson, Figtree has been recognized for her work with baby heart conditions,[5] cardiovascular disease, and heart attacks in people who are not identified as "at risk",[6][1] and leads the Federal Mission for Cardiovascular Health.[2]

Selected publications

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Year TItle Journal
2021 The health digital twin: advancing precision cardiovascular medicine[4] Nature Reviews Cardiology
2021 Mortality in STEMI patients without standard modifiable risk factors: a sex-disaggregated analysis of SWEDEHEART registry data[7] The Lancet
2020 Using machine learning to ace cardiovascular risk tests[8] Cardiovascular Research
2021 FXYD1 Is Protective Against Vascular Dysfunction[9] Hypertension
2020 Single‐Cell Immune Profiling in Coronary Artery Disease: The Role of State‐of‐the‐Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis[10] Circulation Research
2021 Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART‐CT Study[11] Circulation Research
2021 A Call to Action for New Global Approaches to Cardiovascular Disease Drug Solutions[12] Circulation Research
2021 Bench-to-Bedside in Vascular Medicine: Optimizing the Translational Pipeline for Patients With Peripheral Artery Disease[13] Circulation Research
2021 Coronary artery disease patients without standard modifiable risk factors (SMuRFs)- a forgotten group calling out for new discoveries[14] European Heart Journal
2021 A call to action for new global approaches to cardiovascular disease drug solutions[15] European Heart Journal

Awards

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Figtree was appointed a Member of the Order of Australia in the 2023 Australia Day Honours.[16]

She was awarded a National Health and Medical Research Council (NHMRC) Excellence Award for Top Ranked Practitioner Fellow (Australia), commencing in 2018. In 2019 and 2020 she received the prestigious NSW Ministerial Award for Cardiovascular Research Excellence.[17]

Year Award Organisation
2020 NSW Ministerial Award for Cardiovascular Research Excellence NSW Health + Heart Foundation
2019 NSW Ministerial Award for Cardiovascular Research Excellence NSW Health + Heart Foundation
2018 Excellence Award for Top Ranked Practitioner Fellow (Australia) NHMRC

References

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  1. ^ a b "Winners announced as heart disease attracts NSW's brightest minds - News". www.health.nsw.gov.au. Retrieved 7 April 2022.
  2. ^ a b "Professor Gemma Figtree to lead Mission for Cardiovascular Health". Retrieved 7 April 2022.
  3. ^ a b c d "Professor Gemma Figtree". Heart Research Australia. Retrieved 7 April 2022.
  4. ^ a b Coorey, Genevieve; Figtree, Gemma A.; Fletcher, David F.; Redfern, Julie (December 2021). "The health digital twin: advancing precision cardiovascular medicine". Nature Reviews Cardiology. 18 (12): 803–804. doi:10.1038/s41569-021-00630-4. ISSN 1759-5010. PMID 34642446. S2CID 238640582.
  5. ^ Clun, Rachel (2 August 2019). "'A massive difference': funding for studies in baby heart conditions". The Sydney Morning Herald. Retrieved 7 April 2022.
  6. ^ Research shows heart attacks more likely to be deadly among people with no risk factors, ABC News, 10 March 2021, retrieved 7 April 2022
  7. ^ Figtree, Gemma A; Vernon, Stephen T; Hadziosmanovic, Nermin; Sundström, Johan; Alfredsson, Joakim; Arnott, Clare; Delatour, Vincent; Leósdóttir, Margrét; Hagström, Emil (March 2021). "Mortality in STEMI patients without standard modifiable risk factors: a sex-disaggregated analysis of SWEDEHEART registry data". The Lancet. 397 (10279): 1085–1094. doi:10.1016/S0140-6736(21)00272-5. PMID 33711294. S2CID 232163290.
  8. ^ Bell, James R; Figtree, Gemma A; Drummond, Grant R (1 December 2020). "Using machine learning to ace cardiovascular risk tests". Cardiovascular Research. 116 (14): 2173–2174. doi:10.1093/cvr/cvaa305. ISSN 0008-6363. PMID 33125063.
  9. ^ Bubb, Kristen J.; Tang, Owen; Gentile, Carmine; Moosavi, Seyed M.; Hansen, Thomas; Liu, Chia-Chi; Di Bartolo, Belinda A.; Figtree, Gemma A. (1 June 2021). "FXYD1 Is Protective Against Vascular Dysfunction". Hypertension. 77 (6): 2104–2116. doi:10.1161/HYPERTENSIONAHA.120.16884. PMID 33934624.
  10. ^ Kott, Katharine A.; Vernon, Stephen T.; Hansen, Thomas; de Dreu, Macha; Das, Souvik K.; Powell, Joseph; Fazekas de St Groth, Barbara; Di Bartolo, Belinda A.; McGuire, Helen M.; Figtree, Gemma A. (15 December 2020). "Single‐Cell Immune Profiling in Coronary Artery Disease: The Role of State‐of‐the‐Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis". Journal of the American Heart Association. 9 (24): e017759. doi:10.1161/JAHA.120.017759. PMC 7955359. PMID 33251927.
  11. ^ Kott, Katharine A.; Morel‐Kopp, Marie‐Christine; Vernon, Stephen T.; Takagi, Yuki; Di Bartolo, Belinda A.; Peter, Karlheinz; Yang, Jean Y.; Grieve, Stuart M.; Ward, Christopher; Figtree, Gemma A. (19 October 2021). "Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART‐CT Study". Journal of the American Heart Association. 10 (20): e020604. doi:10.1161/JAHA.120.020604. PMC 8751896. PMID 34622670.
  12. ^ Figtree, Gemma A.; Broadfoot, Keith; Casadei, Barbara; Califf, Robert; Crea, Filippo; Drummond, Grant R.; Freedman, Jane E.; Guzik, Tomasz J.; Harrison, David; Hausenloy, Derek J.; Hill, Joseph A. (13 July 2021). "A Call to Action for New Global Approaches to Cardiovascular Disease Drug Solutions". Circulation. 144 (2): 159–169. doi:10.1161/CIR.0000000000000981. PMID 33876947.
  13. ^ Alsaigh, Tom; Di Bartolo, Belinda A.; Mulangala, Jocelyne; Figtree, Gemma A.; Leeper, Nicholas J. (11 June 2021). "Bench-to-Bedside in Vascular Medicine: Optimizing the Translational Pipeline for Patients With Peripheral Artery Disease". Circulation Research. 128 (12): 1927–1943. doi:10.1161/CIRCRESAHA.121.318265. PMC 8208504. PMID 34110900.
  14. ^ Figtree, Gemma A; Vernon, Stephen T (1 June 2021). "Coronary artery disease patients without standard modifiable risk factors (SMuRFs)- a forgotten group calling out for new discoveries". Cardiovascular Research. 117 (6): e76–e78. doi:10.1093/cvr/cvab145. ISSN 0008-6363. PMID 34037711.
  15. ^ Figtree, Gemma A; Broadfoot, Keith; Casadei, Barbara; Califf, Robert; Crea, Filippo; Drummond, Grant R; Freedman, Jane E; Guzik, Tomasz J; Harrison, David; Hausenloy, Derek J; Hill, Joseph A (14 April 2021). "A call to action for new global approaches to cardiovascular disease drug solutions". European Heart Journal. 42 (15): 1464–1475. doi:10.1093/eurheartj/ehab068. ISSN 0195-668X. PMID 33847746.
  16. ^ "Australia Day 2023 Honours: Full list". The Sydney Morning Herald. 25 January 2023. Retrieved 25 January 2023.
  17. ^ "Sydney academics recognised for cardiovascular research excellence". The University of Sydney. Retrieved 7 April 2022.
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